The library has been assembled from commercial and other non-pharmaceutical sources, with some parts of the library acquired under exclusive agreements. Overall, Addex chemists had assembled more than 70,000 compounds. The Addex selection process includes filtering for basic drug-like characteristics and development potential. An additional level of filtering involves the application of proprietary algorithms focused on identifying characteristics of allosteric molecules. A multivariable analysis of the Addex library, depicted here, shows that while its molecules share the physicochemical properties of marketed drugs they are structurally differentiated.
The implications are:
1. Allosteric modulators are not in the same structural space where pharma chemists are used to working. As a result, Addex has built not only a unique library but also multidisciplinary know-how pertaining to different kinds of chemical structures.
2. Intellectual property within the allosteric structural space is relatively unexploited, making discovery and optimization less encumbered by the need to avoid pre-existing patent families, which can often be a challenge for traditional small molecule chemistry efforts.