Allosteric modulators are an emerging class of orally available small molecule therapeutic agents that may offer a competitive advantage over classical drugs.
Allosteric modulators are an emerging class of orally available small molecule therapeutic agents that may offer a competitive advantage over classical drugs. This potential stems from their ability to offer greater selectivity and better modulatory control at disease mediating receptors. Most marketed drugs bind receptors where the body’s own natural molecular activators (i.e. endogenous ligands) bind, specifically to a key part of each receptor’s anatomy called the “active site”. In short, most drugs must out-compete endogenous ligands in order to bind to the active site.Read more
Addex is the first company that has developed patented high-throughput industrial discovery tools for allosteric modulators. Addex has developed proprietary real time kinetic and proximal detection systems that permit the identification of allosteric modulators which modify the molecular response of their target. The outcome of the GLP-1 receptor screening and development of assays leading to the discovery of TNFR1 NAM and IL-1R1 NAM illustrate the power of the unique and proprietary technologies discovered and used at Addex.Read more